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Article

The SAM domain of ANKS6 has different interacting partners and mutations can induce different cystic phenotypes.

Kidney international - 1 Aug 2015

Bakey Zeineb, Bihoreau Marie-Thérèse, Piedagnel Rémi, Delestré Laure, Arnould Catherine, de Villiers Alexandre d'Hotman, Devuyst Olivier, Hoffmann Sigrid, Ronco Pierre, Gauguier Dominique, Lelongt Brigitte

Abstract excerpt

The ankyrin repeat and sterile α motif (SAM) domain-containing six gene (Anks6) is a candidate for polycystic kidney disease (PKD). Originally identified in the PKD/Mhm(cy/+) rat model of PKD, the disease is caused by a mutation (R823W) in the SAM domain of the encoded protein. Recent studies support the etiological role of the ANKS6 SAM domain in human cystic diseases, but its function in kidney remains unknown....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26039630
DOI: 10.1038/ki.2015.122

Genes

BICC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The SAM domain of ANKS6 has different interacting partners and mutations can induce different cystic phenotypes.PMID 26039630Read ↗

ANKS3 Co-Localises with ANKS6 in Mouse Renal Cilia and Is Associated with Vasopressin Signaling and Apoptosis In Vivo in Mice.Semantic proximity Read ↗

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The Inv compartment of renal cilia is an intraciliary signal-activating center to phosphorylate ANKS6.Semantic proximity Read ↗

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