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Article

Structural modeling of human AKAP3 protein and in silico analysis of single nucleotide polymorphisms associated with sperm motility.

Scientific reports - 7 Mar 2022

Rafaee Alemeh, Kashani-Amin Elaheh, Meybodi Anahita Mohseni, Ebrahim-Habibi Azadeh, Sabbaghian Marjan

Abstract excerpt

AKAP3 is a member of the A-kinase anchoring proteins and it is a constituent of the sperm fibrous sheath. AKAP3 is needed for the formation of sperm flagellum structure, sperm motility, and male fertility. This study aims to model the AKAP3 tertiary structure and identify the probable impact of four mutations characterized in infertile men on the AKAP3 structure. The T464S, I500T, E525K, and I661T substitutions...

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Share to A Kinase Anchor Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 35256641
DOI: 10.1038/s41598-022-07513-9
PMCID: PMC8901789

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