Article
Mycobacterium tuberculosis pncA Polymorphisms That Do Not Confer Pyrazinamide Resistance at a Breakpoint Concentration of 100 Micrograms per Milliliter in MGIT.
Journal of clinical microbiology - 1 Nov 2015
Whitfield Michael G, Warren Robin M, Streicher Elizabeth M, Sampson Samantha L, Sirgel Frik A, van Helden Paul D, Mercante Alexandra, Willby Melisa, Hughes Kelsey, Birkness Kris, Morlock Glenn, van Rie Annelies, Posey James E
Abstract excerpt
Sequencing of the Mycobacterium tuberculosis pncA gene allows for pyrazinamide susceptibility testing. We summarize data on pncA polymorphisms that do not confer resistance at a susceptibility breakpoint of 100 μg/ml pyrazinamide in MGIT within a cohort of isolates from South Africa and the U.S. Centers for Disease Control and Prevention.
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