Article
Identification and Correction of Sample Mix-Ups in Expression Genetic Data: A Case Study.
G3 (Bethesda, Md.) - 19 Aug 2015
Broman Karl W, Keller Mark P, Broman Aimee Teo, Kendziorski Christina, Yandell Brian S, Sen Śaunak, Attie Alan D
Abstract excerpt
In a mouse intercross with more than 500 animals and genome-wide gene expression data on six tissues, we identified a high proportion (18%) of sample mix-ups in the genotype data. Local expression quantitative trait loci (eQTL; genetic loci influencing gene expression) with extremely large effect were used to form a classifier to predict an individual's eQTL genotype based on expression data alone. By considering...
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