Article
Integration of carbohydrate metabolism and redox state controls dauer larva formation in Caenorhabditis elegans.
Nature communications - 20 Aug 2015
Penkov Sider, Kaptan Damla, Erkut Cihan, Sarov Mihail, Mende Fanny, Kurzchalia Teymuras V
Abstract excerpt
Under adverse conditions, Caenorhabditis elegans enters a diapause stage called the dauer larva. External cues signal the nuclear hormone receptor DAF-12, the activity of which is regulated by its ligands: dafachronic acids (DAs). DAs are synthesized from cholesterol, with the last synthesis step requiring NADPH, and their absence stimulates dauer formation. Here we show that NADPH levels determine dauer...
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