Article
The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.
Aging cell - 1 Oct 2011
Wollam Joshua, Magomedova Lilia, Magner Daniel B, Shen Yidong, Rottiers Veerle, Motola Daniel L, Mangelsdorf David J, Cummins Carolyn L, Antebi Adam
Abstract excerpt
Bile acids are cholesterol-derived signaling molecules that regulate mammalian metabolism through sterol-sensing nuclear receptor transcription factors. In C. elegans, bile acid-like steroids called dafachronic acids (DAs) control developmental timing and longevity by activating the nuclear receptor DAF-12. However, little is known about the biosynthesis of these molecules. Here, we show that the DAF-36/Rieske...
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