Article
No Significant Increase in the Δ4- and Δ7-Dafachronic Acid Concentration in the Long-Lived glp-1 Mutant, nor in the Mutants Defective in Dauer Formation.
G3 (Bethesda, Md.) - 12 May 2015
Li Tie-Mei, Liu Weilong, Lu Shan, Zhang Yan-Ping, Jia Le-Mei, Chen Jie, Li Xiangke, Lei Xiaoguang, Dong Meng-Qiu
Abstract excerpt
The steroid hormone dafachronic acid (DA) regulates dauer formation and lifespan in Caenorhabditis elegans by binding to the nuclear receptor DAF-12. However, little is known about how DA concentrations change under various physiologic conditions and about how DA/DAF-12 signaling interacts with other signaling pathways that also regulate dauer formation and lifespan. Using a sensitive bioanalytical method, we...
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