Article
Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1.
Scientific reports - 20 Aug 2015
Yu Rilei, Seymour Victoria A L, Berecki Géza, Jia Xinying, Akcan Muharrem, Adams David J, Kaas Quentin, Craik David J
Abstract excerpt
Cyclic α-conotoxin Vc1.1 (cVc1.1) is an orally active peptide with analgesic activity in rat models of neuropathic pain. It has two disulfide bonds, which can have three different connectivities, one of which is the native and active form. In this study we used computational modeling and nuclear magnetic resonance to design a disulfide-deleted mutant of cVc1.1, [C2H,C8F]cVc1.1, which has a larger hydrophobic core...
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