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Article

Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727.

Nature - 3 Jan 2018

Robertson Nathan, Rappas Mathieu, Doré Andrew S, Brown Jason, Bottegoni Giovanni, Koglin Markus, Cansfield Julie, Jazayeri Ali, Cooke Robert M, Marshall Fiona H

Abstract excerpt

The complement system is a crucial component of the host response to infection and tissue damage. Activation of the complement cascade generates anaphylatoxins including C5a and C3a. C5a exerts a pro-inflammatory effect via the G-protein-coupled receptor C5a anaphylatoxin chemotactic receptor 1 (C5aR1, also known as CD88) that is expressed on cells of myeloid origin. Inhibitors of the complement system have long...

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PMID: 29300009
DOI: 10.1038/nature25025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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