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Article

The role of germline mutations in the BRCA1/2 and mismatch repair genes in men ascertained for early-onset and/or familial prostate cancer.

Familial cancer - 1 Jan 2016

Maia Sofia, Cardoso Marta, Paulo Paula, Pinheiro Manuela, Pinto Pedro, Santos Catarina, Pinto Carla, Peixoto Ana, Henrique Rui, Teixeira Manuel R

Abstract excerpt

Prostate cancer (PrCa) is one of the most common cancers diagnosed worldwide and 5-10 % of all cases are estimated to be associated with inherited predisposition. Even though there is strong evidence that the genetic component is significant in PrCa, the genetic etiology of familial and early-onset disease is largely unknown. Although it has been suggested that men from families with hereditary breast/ovarian...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26289772
DOI: 10.1007/s10689-015-9832-x

Genes

MSH2
BRCA1
BRCA2
MLH1
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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