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Subgroups of familial and aggressive prostate cancer with considerable frequencies of BRCA2 mutations.

The Prostate - 1 Oct 2014

Maier Christiane, Herkommer Kathleen, Luedeke Manuel, Rinckleb Antje, Schrader Mark, Vogel Walther

Abstract excerpt

BACKGROUND: One of the known risk factors for prostate cancer (PrCa) is germline mutations in the BRCA2 gene. Previous searches for clinical characteristics which could identify a subgroup of patients enriched for mutation carriers revealed early onset and aggressive PrCa as useful parameters, but they are rather unspecific. METHODS: Identification of BRCA2 mutation carriers by sequencing all exons of BRCA2 in a...

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Identifiers

PMID: 25111659
DOI: 10.1002/pros.22860

Genes

BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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