Brain-derived neurotrophic factor genetic polymorphism (rs6265) is protective against chemotherapy-associated cognitive impairment in patients with early-stage breast cancer.

doi:10.1093/neuonc/nov162

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Brain-derived neurotrophic factor genetic polymorphism (rs6265) is protective against chemotherapy-associated cognitive impairment in patients with early-stage breast cancer.

Neuro-oncology - 1 Feb 2016

Ng Terence, Teo Shu Mei, Yeo Hui Ling, Shwe Maung, Gan Yan Xiang, Cheung Yin Ting, Foo Koon Mian, Cham Mooi Tai, Lee Jung Ah, Tan Yee Pin, Fan Gilbert, Yong Wei Sean, Preetha Madhukumar, Loh Wei-Jen Kiley, Koo Si-Lin, Jain Amit, Lee Guek Eng, Wong Mabel, Dent Rebecca, Yap Yoon Sim, Ng Raymond, Khor Chiea Chuen, Ho Han Kiat, Chan Alexandre

Abstract excerpt

BACKGROUND: Brain-derived neurotrophic factor (BDNF), a neurotrophin that regulates neuronal function and development, is implicated in several neurodegenerative conditions. Preliminary data suggest that a reduction of BDNF concentrations may lead to postchemotherapy cognitive impairment. We hypothesized that a single nucleotide polymorphism (rs6265) of the BDNF gene may predispose patients to cognitive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antineoplastic Combined Chemotherapy Protocols

Share to Biomarkers, Tumor

Share to Brain-Derived Neurotrophic Factor

Share to Breast Neoplasms

Share to Cognition Disorders

Share to Follow-Up Studies

Share to Neoplasm Staging

Share to Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 26289590
DOI: 10.1093/neuonc/nov162
PMCID: PMC4724179

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brain-derived neurotrophic factor genetic polymorphism (rs6265) is protective against chemotherapy-associated cognitive impairment in patients with early-stage breast cancer.PMID 26289590Read ↗

Associations of plasma brain-derived neurotrophic factor (BDNF) and Val66Met polymorphism (rs6265) with long-term cancer-related cognitive impairment in survivors of breast cancer.Semantic proximity Read ↗

Associations of brain-derived neurotrophic factor rs6265 polymorphism and cognitive function in breast cancer survivors from a cross-sectional study.Semantic proximity Read ↗

Evaluation of plasma brain-derived neurotrophic factor levels and self-perceived cognitive impairment post-chemotherapy: a longitudinal study.Semantic proximity Read ↗

Brain-derived neurotrophic factor as a biomarker in cancer-related cognitive impairment among adolescent and young adult cancer patients.Semantic proximity Read ↗

Associations of BDNF methylation and rs6265 genotype with cognitive response to a six-month aerobic exercise intervention in women with early-stage breast cancer: results from the EPICC Trial.Semantic proximity Read ↗

Impact of brain-derived neurotrophic factor genetic polymorphism on cognition: A systematic review.Semantic proximity Read ↗

Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression.Semantic proximity Read ↗

The association of genetic polymorphisms with neuroconnectivity in breast cancer patients.Semantic proximity Read ↗

Val66Met BDNF polymorphism as a vulnerability factor for inflammation-associated depressive symptoms in women with breast cancer.Semantic proximity Read ↗

Protective Effects of APOE ε2 Genotype on Cognition in Older Breast Cancer Survivors: The Thinking and Living With Cancer Study.Semantic proximity Read ↗

Brain-derived neurotrophic factor polymorphism Val66Met protects against cancer-related fatigue.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.