Article
Associations of plasma brain-derived neurotrophic factor (BDNF) and Val66Met polymorphism (rs6265) with long-term cancer-related cognitive impairment in survivors of breast cancer.
Breast cancer research and treatment - 1 Oct 2020
Yap Ning Yi, Tan Nichole Yue Ting, Tan Chia Jie, Loh Kiley Wei-Jen, Ng Raymond Chee Hui, Ho Han Kiat, Chan Alexandre
Abstract excerpt
PURPOSE: Brain-derived neurotrophic factor (BDNF) and the BDNF Val66Met polymorphism (rs6265) have been implicated in neurodegenerative conditions. This study aimed to investigate the associations of plasma BDNF and rs6265 with cancer-related cognitive impairment (CRCI) at the end of chemotherapy, and with persistent and delayed CRCI up to 24 months post chemotherapy, among survivors of early-stage breast cancer....
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