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Article

Brain-derived neurotrophic factor as a biomarker in cancer-related cognitive impairment among adolescent and young adult cancer patients.

Scientific reports - 28 Sept 2023

Ng Ding Quan, Cheng Ivy, Wang Claire, Tan Chia Jie, Toh Yi Long, Koh Yong Qin, Ke Yu, Foo Koon Mian, Chan Raymond J, Ho Han Kiat, Chew Lita, Bin Harunal Rashid Mohamad Farid, Chan Alexandre

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) improves cognitive function by stimulating neurogenesis and neuroplasticity. We hypothesize that higher plasma BDNF levels are protective against cognitive toxicity among adolescent and young adult cancer patients (15-39 years old). In a prospective, longitudinal study, we recruited 74 newly diagnosed cancer and 118 age-matched non-cancer controls who completed the...

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PMID: 37770565
DOI: 10.1038/s41598-023-43581-1
PMCID: PMC10539508

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