Associations of BDNF methylation and rs6265 genotype with cognitive response to a six-month aerobic exercise intervention in women with early-stage breast cancer: results from the EPICC Trial.

doi:10.1007/s11357-025-02004-x

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Associations of BDNF methylation and rs6265 genotype with cognitive response to a six-month aerobic exercise intervention in women with early-stage breast cancer: results from the EPICC Trial.

GeroScience - 1 Apr 2026

Cho Myeong-Ga, Sereika Susan M, Cummings Meredith, King Lucia, Erickson Kirk I, Bender Catherine M, Conley Yvette P

Abstract excerpt

Women with breast cancer often experience cognitive decline, an accelerated aging phenotype. While aerobic exercise may mitigate this decline, effects are inconsistent by domains, and the molecular mechanisms remain unknown. Given the brain-derived neurotrophic factor (BDNF)'s responsiveness to exercise and role in cognition, we investigated BDNF methylation and rs6265, its functional SNP, with cognitive...

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PMID: 41252084
DOI: 10.1007/s11357-025-02004-x
PMCID: PMC12972165

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BDNF

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