Article
Association of MDR1 gene (C3435T) polymorphism and gene expression profiling in lung cancer patients treated with platinum-based chemotherapy.
Molecular diagnosis & therapy - 1 Oct 2015
Subhani Syed, Jamil Kaiser, Nirni Sharanabasappa Somanath
Abstract excerpt
INTRODUCTION: Chemotherapy is the standard and recommended treatment for lung cancer apart from surgery and radiotherapy. Chemotherapy is administered as mono-agents or as combination therapy. In this study, we examined the role of MDR1 C3435T polymorphisms in lung cancer patients undergoing chemotherapy. METHODS AND RESULTS: We genotyped 126 cases with lung cancer and 111 healthy controls, using the polymerase...
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