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Article

MDR1 polymorphisms predict the response to etoposide-cisplatin combination chemotherapy in small cell lung cancer.

Japanese journal of clinical oncology - 1 Mar 2006

Sohn Ji Woong, Lee Shin Yup, Lee Su Jung, Kim Eun Jin, Cha Seung Ick, Kim Chang Ho, Lee Jae-Tae, Jung Tae Hoon, Park Jae Yong

Abstract excerpt

BACKGROUND: The MDR1 gene encodes P-glycoprotein (PGP), which plays an important role in mediating multidrug resistance to chemotherapeutic agents. Polymorphisms in the MDR1 gene may have an impact on the expression and function of PGP, thereby influencing the response to chemotherapy. METHODS: We investigated the potential association of MDR1 polymorphisms (2677G>T at exon 21 and 3435C>T at exon 26) and their...

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Share to Antineoplastic Combined Chemotherapy Protocols
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16478794
DOI: 10.1093/jjco/hyi231

Genes

PGP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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