Article
hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells.
Molecular and cellular neurosciences - 1 Sept 2015
DeRosa Brooke A, Belle Kinsley C, Thomas Blake J, Cukier Holly N, Pericak-Vance Margaret A, Vance Jeffery M, Dykxhoorn Derek M
Abstract excerpt
BACKGROUND: GABAergic synaptic transmission is known to play a critical role in the assembly of neuronal circuits during development and is responsible for maintaining the balance between excitatory and inhibitory signaling in the brain during maturation into adulthood. Importantly, defects in GABAergic neuronal function and signaling have been linked to a number of neurological diseases, including autism...
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