Article
Diet- and Genetically-Induced Obesity Differentially Affect the Fecal Microbiome and Metabolome in Apc1638N Mice.
PloS one - 1 Jan 2015
Pfalzer Anna C, Nesbeth Paula-Dene C, Parnell Laurence D, Iyer Lakshmanan K, Liu Zhenhua, Kane Anne V, Chen C-Y Oliver, Tai Albert K, Bowman Thomas A, Obin Martin S, Mason Joel B, Greenberg Andrew S, Choi Sang-Woon, Selhub Jacob, Paul Ligi, Crott Jimmy W
Abstract excerpt
Obesity is a risk factor for colorectal cancer (CRC), and alterations in the colonic microbiome and metabolome may be mechanistically involved in this relationship. The relative contribution of diet and obesity per se are unclear. We compared the effect of diet- and genetically-induced obesity on the intestinal microbiome and metabolome in a mouse model of CRC. Apc1638N mice were made obese by either high fat...
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