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Article

Microbiota in mesenteric adipose tissue from Crohn’s disease promote colitis in mice

23 Nov 2021

Abstract excerpt

Abstract Background Mesenteric adipose tissue (mAT) hyperplasia, known as creeping fat is a pathologic characteristic of Crohn’s disease (CD). The reserve of creeping fat in surgery is associated with poor prognosis of CD patients, but the mechanism remains unknown. Methods Mesenteric microbiome, metabolome, and host transcriptome were characterized using a cohort of 48 patients with CD and 16 non-CD controls....

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PMID: 34814945
DOI: 10.1186/s40168-021-01178-8

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