Article

Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer

2023-03-18

Abstract excerpt

Western diet is an important risk factor for the development of sporadic colorectal cancer (CRC). Dietary fat stimulates bile acid (BA) production by the host and their conversion to secondary BAs by 7α-dehydroxylating (7αDH+) bacteria, but causal proof of their tumor-promoting effects in vivo is lacking. To address this, we performed feeding studies in a genetically engineered pig model of CRC combined with mult...

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Literature Corpus work: 0cc21719-cd31-5019-a614-05a221f94419
DOI: 10.1101/2023.03.17.533140

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