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Article

Altered gut microbiota of obesity subjects promotes colorectal carcinogenesis in mice

19 Jun 2023

Abstract excerpt

BACKGROUND: Obesity is a risk factor for colorectal cancer (CRC). The role of gut microbiota in mediating the cancer-promoting effect of obesity is unknown. METHODS: and germ-free mice were gavaged with feces from obese individuals and control subjects respectively. The colonic tumor load and number were recorded at the endpoint in two carcinogenic models. The gut microbiota composition and colonic transcriptome...

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PMID: 37343363
DOI: 10.1016/j.ebiom.2023.104670

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