Article
A CC' loop decoy peptide blocks the interaction between Act1 and IL-17RA to attenuate IL-17- and IL-25-induced inflammation.
Science signaling - 1 Nov 2011
Liu Caini, Swaidani Shadi, Qian Wen, Kang Zizhen, Sun Paige, Han Yue, Wang Chenhui, Gulen Muhammet Fatih, Yin Weiguo, Zhang Chunjiang, Fox Paul L, Aronica Mark, Hamilton Thomas A, Misra Saurav, Deng Junpeng, Li Xiaoxia
Abstract excerpt
Interleukin-17 (IL-17) and IL-25 signaling induce the expression of genes encoding inflammatory factors and are implicated in the pathology of various inflammatory diseases. Nuclear factor κB (NF-κB) activator 1 (Act1) is an adaptor protein and E3 ubiquitin ligase that is critical for signaling by either IL-17 or IL-25, and it is recruited to their receptors (IL-17R and IL-25R) through heterotypic interactions...
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