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Article

Colorectal cancer: a multipathway disease.

Critical reviews in oncogenesis - 1 Dec 2006

Jass Jeremy R

Abstract excerpt

The linear sequence of genetic alterations illustrated in the Vogelstein model provides a readily understandable illustration of the fundamental principles underlying colorectal tumorigenesis. However, it is now clear that colorectal cancer is a multi-pathway disease. In this review, the concept that inactivation of the tumor suppressor gene APC serves to initiate virtually all colorectal cancers is shown to be...

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Source

Identifiers

PMID: 17425506
DOI: 10.1615/critrevoncog.v12.i3-4.50

Genes

APC
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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