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Article

AMP-activated protein kinase suppresses arachidonate 15-lipoxygenase expression in interleukin 4-polarized human macrophages.

The Journal of biological chemistry - 2 Oct 2015

Namgaladze Dmitry, Snodgrass Ryan G, Angioni Carlo, Grossmann Nina, Dehne Nathalie, Geisslinger Gerd, Brüne Bernhard

Abstract excerpt

Macrophages respond to the Th2 cytokine IL-4 with elevated expression of arachidonate 15-lipoxygenase (ALOX15). Although IL-4 signaling elicits anti-inflammatory responses, 15-lipoxygenase may either support or inhibit inflammatory processes in a context-dependent manner. AMP-activated protein ki...

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Source

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Identifiers

PMID: 26276392
DOI: 10.1074/jbc.M115.678243
PMCID: PMC4591829

Genes

ALOX15
STAT6
CXCL10
CXCL9
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26276392-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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