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Exenatide and metformin express their anti-inflammatory effects on human monocytes/macrophages by the attenuation of MAPKs and NFκB signaling.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Oct 2016

Bułdak Łukasz, Machnik Grzegorz, Bułdak Rafał Jakub, Łabuzek Krzysztof, Bołdys Aleksandra, Okopień Bogusław

Abstract excerpt

Metformin and exenatide are effective antidiabetic drugs, and they seem to have pleiotropic properties improving cardiovascular outcomes. Macrophages' phenotype is essential in the development of atherosclerosis, and it can be modified during antidiabetic therapy, resulting in attenuated atherogenesis. The mechanism orchestrating this phenomenon is not fully clear. We examined the impact of exenatide and...

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Identifiers

PMID: 27424158
DOI: 10.1007/s00210-016-1277-8

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EBP
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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