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Article

AICAR inhibits PPARγ during monocyte differentiation to attenuate inflammatory responses to atherogenic lipids.

Cardiovascular research - 1 Jun 2013

Namgaladze Dmitry, Kemmerer Marina, von Knethen Andreas, Brüne Bernhard

Abstract excerpt

AIMS: Transcriptional regulation through peroxisome proliferator-activated receptor γ (PPARγ) is critical for an altered lipid metabolism during monocyte to macrophage differentiation. Here, we investigated how 5-aminoimidazole-4-carboxamide riboside (AICAR), an activator of AMP-dependent protein kinase (AMPK), affects PPARγ during monocyte differentiation. METHODS AND RESULTS: During the differentiation of THP-1...

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Source

Identifiers

PMID: 23531513
DOI: 10.1093/cvr/cvt073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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