Article
LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPARγ ligand synthesis.
Nature communications - 15 Apr 2015
Lefèvre Lise, Authier Hélène, Stein Sokrates, Majorel Clarisse, Couderc Bettina, Dardenne Christophe, Eddine Mohamad Ala, Meunier Etienne, Bernad José, Valentin Alexis, Pipy Bernard, Schoonjans Kristina, Coste Agnès
Abstract excerpt
Liver receptor homologue-1 (LRH-1) is a nuclear receptor involved in the repression of inflammatory processes in the hepatointestinal tract. Here we report that LRH-1 is expressed in macrophages and induced by the Th2 cytokine IL-13 via a mechanism involving STAT6. We show that loss-of-function of LRH-1 in macrophages impedes IL-13-induced macrophage polarization due to impaired generation of 15-HETE PPARγ...
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