Article
The ancient drug salicylate directly activates AMP-activated protein kinase.
Science (New York, N.Y.) - 18 May 2012
Hawley Simon A, Fullerton Morgan D, Ross Fiona A, Schertzer Jonathan D, Chevtzoff Cyrille, Walker Katherine J, Peggie Mark W, Zibrova Darya, Green Kevin A, Mustard Kirsty J, Kemp Bruce E, Sakamoto Kei, Steinberg Gregory R, Hardie D Grahame
Abstract excerpt
Salicylate, a plant product, has been in medicinal use since ancient times. More recently, it has been replaced by synthetic derivatives such as aspirin and salsalate, both of which are rapidly broken down to salicylate in vivo. At concentrations reached in plasma after administration of salsalate or of aspirin at high doses, salicylate activates adenosine monophosphate-activated protein kinase (AMPK), a central...
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