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Article

The Human Myotrophin Variant Attenuates MicroRNA-Let-7 Binding Ability but Not Risk of Left Ventricular Hypertrophy in Human Essential Hypertension.

PloS one - 1 Jan 2015

Wang Yuyao, Chen Jingzhou, Song Weihua, Wang Yuxuan, Chen Yu, Nie Yu, Ye Zhidong, Hui Rutai

Abstract excerpt

Myotrophin, known as a myocardial hypertrophy-inducing factor, is responsible for the initiation of cardiac hypertrophy that transits to heart failure. MicroRNAs are small noncoding RNAs that down-regulate posttranscriptional expression of target molecules. We investigated the role of variants of the microRNA-binding site in myotrophin in affecting its expression and any association with cardiac hypertrophy....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypertrophy, Left Ventricular

Share to Intercellular Signaling Peptides and Proteins

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Source

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Identifiers

PMID: 26274321
DOI: 10.1371/journal.pone.0135526
PMCID: PMC4537090

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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