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Article

Direct and Indirect Involvement of MicroRNA-499 in Clinical and Experimental Cardiomyopathy

1 Jul 2012

Abstract excerpt

RATIONALE: MicroRNA-499 and other members of the myomiR family regulate myosin isoforms in pressure-overload hypertrophy. miR-499 expression varies in human disease, but results of mouse cardiac miR-499 overexpression are inconsistent, either protecting against ischemic damage or aggravating cardiomyopathy after pressure overload. Likewise, there is disagreement over direct and indirect cardiac mRNAs targeted in...

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PMID: 22752967
DOI: 10.1161/circresaha.112.265736

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