Article
Common miR-590 Variant rs6971711 Present Only in African Americans Reduces miR-590 Biogenesis.
PloS one - 1 Jan 2016
Lin Xiaoping, Steinberg Steven, Kandasamy Suresh K, Afzal Junaid, Mbiyangandu Blaid, Liao Susan E, Guan Yufan, Corona-Villalobos Celia P, Matkovich Scot J, Epstein Neal, Tripodi Dotti, Huo Zhaoxia, Cutting Garry, Abraham Theodore P, Fukunaga Ryuya, Abraham M Roselle
Abstract excerpt
MicroRNAs (miRNAs) are recognized as important regulators of cardiac development, hypertrophy and fibrosis. Recent studies have demonstrated that genetic variations which cause alterations in miRNA:target interactions can lead to disease. We hypothesized that genetic variations in miRNAs that regulate cardiac hypertrophy/fibrosis might be involved in generation of the cardiac phenotype in patients diagnosed with...
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