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Article

A functional variant in the coding region of CAMTA2 is associated with left ventricular hypertrophy by affecting the activation of Nkx2.5-dependent transcription.

Journal of hypertension - 1 May 2016

Song Wei-Hua, Lin Ya-Hui, Sun Kai, Zhang Yin-Hui, Song Yan, Hou Li-Bo, Zhang Chan-Na, Hui Ru-Tai, Chen Jing-Zhou

Abstract excerpt

OBJECTIVE: The calmodulin-binding transcription activator 2 (CAMTA2) promotes transcription of genes involved in cardiac hypertrophy through its interaction with Nkx2.5 and is an indispensable transcription coactivator for cardiac hypertrophy. We hypothesized that variants in the coding region of CAMTA2 would affect its function and confer a risk of cardiac hypertrophy. METHODS: The effects of the variant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Homeobox Protein Nkx-2.5

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Source

Identifiers

PMID: 26886562
DOI: 10.1097/HJH.0000000000000873

Genes

CAMTA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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