Article
Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics.
Current topics in behavioral neurosciences - 1 Jan 2016
Kazdoba Tatiana M, Leach Prescott T, Yang Mu, Silverman Jill L, Solomon Marjorie, Crawley Jacqueline N
Abstract excerpt
Animal models provide preclinical tools to investigate the causal role of genetic mutations and environmental factors in the etiology of autism spectrum disorder (ASD). Knockout and humanized knock-in mice, and more recently knockout rats, have been generated for many of the de novo single gene mutations and copy number variants (CNVs) detected in ASD and comorbid neurodevelopmental disorders. Mouse models...
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