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Article

NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show divergent metabolic effects.

Human molecular genetics - 15 Jun 2018

Sliz Eeva, Sebert Sylvain, Würtz Peter, Kangas Antti J, Soininen Pasi, Lehtimäki Terho, Kähönen Mika, Viikari Jorma, Männikkö Minna, Ala-Korpela Mika, Raitakari Olli T, Kettunen Johannes

Abstract excerpt

Fatty liver has been associated with unfavourable metabolic changes in circulation. To provide insights in fatty liver-related metabolic deviations, we compared metabolic association profile of fatty liver versus metabolic association profiles of genotypes increasing the risk of non-alcoholic fatty liver disease (NAFLD). The cross-sectional associations of ultrasound-ascertained fatty liver with 123 metabolic...

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Identifiers

PMID: 29648650
DOI: 10.1093/hmg/ddy124
PMCID: PMC5985737

Genes

GCKR
LYPLAL1
PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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