Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Determinants of Circulating Lipoproteins in Nonalcoholic Fatty Liver Disease.

Journal of clinical gastroenterology - 1 Jan 2000

Jiang Zhenghui G, Tapper Elliot B, Kim Misung, Connelly Margery A, Krawczyk Sarah A, Yee Eric U, Herman Mark A, Mukamal Kenneth J, Lai Michelle

Abstract excerpt

BACKGROUND: Recent genome-wide association studies have identified 2 genetic polymorphisms in association with nonalcoholic fatty liver disease (NAFLD): patatin-like phospholipase domain containing 3 (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2), both of which appear to influence the production of very low density lipoprotein (VLDL). The impact of these genetic variations on lipoprotein metabolism in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lipase
Share to Lipoproteins, HDL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipoproteins, LDL

Share to Lipoproteins, VLDL

Share to Liver Cirrhosis

Share to Magnetic Resonance Spectroscopy

Share to Membrane Proteins

Share to Non-alcoholic Fatty Liver Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 28362682
DOI: 10.1097/MCG.0000000000000816
PMCID: PMC5623166

Genes

PNPLA3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Determinants of Circulating Lipoproteins in Nonalcoholic Fatty Liver Disease.PMID 28362682Read ↗

Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis.Semantic proximity Read ↗

Genetics of nonalcoholic fatty liver disease.Semantic proximity Read ↗

PNPLA3 I148M variant in nonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis.Semantic proximity Read ↗

Significance of genetic polymorphisms in patients with nonalcoholic fatty liver disease.Semantic proximity Read ↗

Treating liver fat and serum triglyceride levels in NAFLD, effects of PNPLA3 and TM6SF2 genotypes: Results from the WELCOME trial.Semantic proximity Read ↗

NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show divergent metabolic effects.Semantic proximity Read ↗

Metabolic effects of risk alleles in <i>PNPLA3, TM6SF2, GCKR</i> and <i>LYPLAL1</i> inform about heterogeneity of non-alcoholic fatty liver diseaseSemantic proximity Read ↗

Review article: the emerging role of genetics in precision medicine for patients with non-alcoholic steatohepatitis.Semantic proximity Read ↗

Non-alcoholic fatty liver disease and subclinical atherosclerosis: A comparison of metabolically- versus genetically-driven excess fat hepatic storage.Semantic proximity Read ↗

Hepatic patatin-like phospholipase domain-containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans.Semantic proximity Read ↗

Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2.Semantic proximity Read ↗

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.