Article
Profiling the phospho-status of the BKCa channel alpha subunit in rat brain reveals unexpected patterns and complexity.
Molecular & cellular proteomics : MCP - 1 Nov 2008
Yan Jiusheng, Olsen Jesper V, Park Kang-Sik, Li Weiyan, Bildl Wolfgang, Schulte Uwe, Aldrich Richard W, Fakler Bernd, Trimmer James S
Abstract excerpt
Molecular diversity of ion channel structure and function underlies variability in electrical signaling in nerve, muscle, and non-excitable cells. Protein phosphorylation and alternative splicing of pre-mRNA are two important mechanisms to generate structural and functional diversity of ion channels. However, systematic mass spectrometric analyses of in vivo phosphorylation and splice variants of ion channels in...
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