Article
Polymorphism of DNA Methyltransferase 3b and Association with Development and Prognosis in Gastric Cancer.
PloS one - 1 Jan 2015
Wang Chuan, Jia Zhifang, Cao Donghui, You Lili, Jin Meishan, Wu Xing, Wen Simin, Cao Xueyuan, Jiang Jing
Abstract excerpt
OBJECTIVE: DNA methyltransferase 3b (DNMT3b) plays an important role in abnormal methylation during tumorigenesis. Polymorphism of the DNMT3b gene may influence DNMT3b activity and be associated with cancer risk. This study aimed to investigate the association between single nucleotide polymorphisms (SNPs) of the DNMT3b gene and susceptibility and prognosis of gastric cancer. METHODS: Four hundred and forty-seven...
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