Article
DNMT3A rs36012910 A>G polymorphism and gastric cancer susceptibility in a Chinese population.
Molecular biology reports - 1 Dec 2012
Wu Qunying, Lu Sen, Wang Ling, Hu Jiaojiao, Qiao Fengchang, Qiu Xuemei, Zhao Chengcheng, Lao Yingbin, Song Yunwei, Fan Hong
Abstract excerpt
DNA-methyltransferase (DNMT)-3A plays a crucial role in embryonic development and aberrant DNA methylation in carcinogenesis. Polymorphisms of the DNMT3A gene may influence its enzymatic activity and its contribution to susceptibility to cancer. This study evaluated the association of DNMT3A rs36012910 A>G with susceptibility to gastric cancer (GC) in a Chinese population. Genomic DNA was extracted from samples...
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