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Clinical significance of the expression of DNA methyltransferase proteins in gastric cancer

31 Aug 2011

Abstract excerpt

DNA methyltransferase (DNMT) 1, DNMT3A and DNMT3B, which affect promoter CpG methylation status, play a significant role in cancer development. Little is known regarding the clinical significance of DNMT expression in gastric cancers. Expression of DNMT1, DNMT3A and DNMT3B in paraffin sections from 54 gastric cancer patients were examined using immunohistochemistry, and their associations with the corresponding...

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PMID: 21887466
DOI: 10.3892/mmr.2011.578

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