Article
DNMT3B promoter polymorphism and risk of gastric cancer.
Digestive diseases and sciences - 1 Apr 2010
Hu Jiabo, Fan Hong, Liu Dongsheng, Zhang Shuhong, Zhang Feng, Xu Huaxi
Abstract excerpt
To investigate the association of single-nucleotide polymorphism (SNP) in DNA methyltransferase 3B (DNMT3B) gene and the risk of gastric cancer (GC), we detected -149C>T and -579G>T in the promoter region of the DNMT3B gene by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing analysis. The DNMT3B genotype was determined in 259 gastric cancer patients and 262 healthy...
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