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Article

Enhanced molecular mobility of ordinarily structured regions drives polyglutamine disease.

The Journal of biological chemistry - 2 Oct 2015

Lupton Christopher J, Steer David L, Wintrode Patrick L, Bottomley Stephen P, Hughes Victoria A, Ellisdon Andrew M

Abstract excerpt

Polyglutamine expansion is a hallmark of nine neurodegenerative diseases, with protein aggregation intrinsically linked to disease progression. Although polyglutamine expansion accelerates protein aggregation, the misfolding process is frequently instigated by flanking domains. For example, polyglutamine expansion in ataxin-3 allosterically triggers the aggregation of the catalytic Josephin domain. The molecular...

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Identifiers

PMID: 26260925
DOI: 10.1074/jbc.M115.659532
PMCID: PMC4591807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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