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Article

Capturing the Conformational Ensemble of the Mixed Folded Polyglutamine Protein Ataxin-3.

Structure (London, England : 1993) - 7 Jan 2021

Sicorello Alessandro, Różycki Bartosz, Konarev Petr V, Svergun Dmitri I, Pastore Annalisa

Abstract excerpt

Ataxin-3 is a deubiquitinase involved in protein quality control and other essential cellular functions. It preferentially interacts with polyubiquitin chains of four or more units attached to proteins delivered to the ubiquitin-proteasome system. Ataxin-3 is composed of an N-terminal Josephin domain and a flexible C terminus that contains two or three ubiquitin-interacting motifs (UIMs) and a polyglutamine...

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PMID: 33065068
DOI: 10.1016/j.str.2020.09.010

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