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Article

Flanking domain stability modulates the aggregation kinetics of a polyglutamine disease protein.

Protein science : a publication of the Protein Society - 1 Oct 2011

Saunders Helen M, Gilis Dimitri, Rooman Marianne, Dehouck Yves, Robertson Amy L, Bottomley Stephen P

Abstract excerpt

Spinocerebellar Ataxia Type 3 (SCA3) is one of nine polyglutamine (polyQ) diseases that are all characterized by progressive neuronal dysfunction and the presence of neuronal inclusions containing aggregated polyQ protein, suggesting that protein misfolding is a key part of this disease. Ataxin-3, the causative protein of SCA3, contains a globular, structured N-terminal domain (the Josephin domain) and a flexible...

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Identifiers

PMID: 21780213
DOI: 10.1002/pro.698
PMCID: PMC3218360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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