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Article

Destabilizing the AXH Tetramer by Mutations: Mechanisms and Potential Antiaggregation Strategies.

Biophysical journal - 23 Jan 2018

Grasso Gianvito, Morbiducci Umberto, Massai Diana, Tuszynski Jack A, Danani Andrea, Deriu Marco A

Abstract excerpt

The AXH domain of protein Ataxin 1 is thought to play a key role in the misfolding and aggregation pathway responsible for Spinocerebellar ataxia 1. For this reason, a molecular level understanding of AXH oligomerization pathway is crucial to elucidate the aggregation mechanism, which is thought to trigger the disease. This study employs classical and enhanced molecular dynamics to identify the structural and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29401430
DOI: 10.1016/j.bpj.2017.11.025
PMCID: PMC5984971

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