Article
Identification of an RNA element for specific coordination of A-to-I RNA editing on HTR2C pre-mRNA.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Oct 2015
Fukuda Masatora, Oyama Yui, Nishitarumizu Azusa, Omura Miki, Nose Kanako, Deshimaru Masanobu
Abstract excerpt
Adenosine-to-Inosine (A-to-I) RNA editing is an intracellular mechanism in which inosine is specifically substituted against adenosine by the action of adenosine deaminases acting on RNA (ADARs). Serotonin 2C receptor (HTR2C) is encoded through combinatorial A-to-I RNA editing at recoding sites (A - E site) on its pre-mRNA. Although the efficiency of RNA editing at particular sites is known to be critical for...
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