Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased ID4 expression, accompanied by mutant p53 accumulation and loss of BRCA1/2 proteins in triple-negative breast cancer, adversely affects survival.

Histopathology - 1 Apr 2016

Thike Aye A, Tan Puay H, Ikeda Murasaki, Iqbal Jabed

Abstract excerpt

AIMS: Breast cancer 1 (BRCA1) expression is down-regulated in a significant proportion of non-hereditary breast cancers, in the absence of any mutation. This phenomenon is more pronounced in oestrogen (ER)-negative tumours. Recent studies have suggested that inhibitor of DNA binding 4 (ID4), as well as p53, participate in the transcriptional regulation of BRCA1. METHODS: Immunohistochemical expression of ID4,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to BRCA2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease-Free Survival

Share to Down-Regulation

Share to Neoplasm Recurrence, Local

Share to Singapore

Share to Tissue Array Analysis

Share to Triple Negative Breast Neoplasms

Source

Identifiers

PMID: 26259780
DOI: 10.1111/his.12801

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased ID4 expression, accompanied by mutant p53 accumulation and loss of BRCA1/2 proteins in triple-negative breast cancer, adversely affects survival.PMID 26259780Read ↗

Id4 protein is highly expressed in triple-negative breast carcinomas: possible implications for BRCA1 downregulationSemantic proximity Read ↗

Exploring ID4 as a Driver of Aggression and a Therapeutic Target in Triple-Negative Breast CancerSemantic proximity Read ↗

ID4 controls luminal lineage commitment in normal mammary epithelium and inhibits BRCA1 function in basal-like breast cancerSemantic proximity Read ↗

Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancerSemantic proximity Read ↗

ID4: a new player in the cancer arenaSemantic proximity Read ↗

Evaluation of BRCA1-related molecular features and microRNAs as prognostic factors for triple negative breast cancers.Semantic proximity Read ↗

Aberrant expression of TopBP1 in breast cancer.Semantic proximity Read ↗

Cyclin D1, Id1 and EMT in breast cancerSemantic proximity Read ↗

Expression of thyroid transcription factor-1 is associated with a basal-like phenotype in breast carcinomas.Semantic proximity Read ↗

The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis.Semantic proximity Read ↗

Id1 expression is associated with histological grade and invasive behavior in endometrial carcinomaSemantic proximity Read ↗

Tumoral expression of BRCA1, Estrogen receptor alpha and ID4 protein in patients with sporadic breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.