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Article

Evaluation of BRCA1-related molecular features and microRNAs as prognostic factors for triple negative breast cancers.

BMC cancer - 21 Oct 2015

Boukerroucha Meriem, Josse Claire, ElGuendi Sonia, Boujemla Bouchra, Frères Pierre, Marée Raphaël, Wenric Stephane, Segers Karin, Collignon Joelle, Jerusalem Guy, Bours Vincent

Abstract excerpt

BACKGROUND: The BRCA1 gene plays a key role in triple negative breast cancers (TNBCs), in which its expression can be lost by multiple mechanisms: germinal mutation followed by deletion of the second allele; negative regulation by promoter methylation; or miRNA-mediated silencing. This study aimed to establish a correlation among the BRCA1-related molecular parameters, tumor characteristics and clinical follow-up...

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Topics

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Share to BRCA1 Protein
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Lymph Nodes

Share to Lymphatic Metastasis

Share to MicroRNAs

Share to Neoplasm Recurrence, Local

Share to Triple Negative Breast Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 26490435
DOI: 10.1186/s12885-015-1740-9
PMCID: PMC4618357

Genes

BRCA1
BARD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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