Article
SNP Formation Bias in the Murine Genome Provides Evidence for Parallel Evolution.
Genome biology and evolution - 6 Aug 2015
Plyler Zackery E, Hill Aubrey E, McAtee Christopher W, Cui Xiangqin, Moseley Leah A, Sorscher Eric J
Abstract excerpt
In this study, we show novel DNA motifs that promote single nucleotide polymorphism (SNP) formation and are conserved among exons, introns, and intergenic DNA from mice (Sanger Mouse Genomes Project), human genes (1000 Genomes), and tumor-specific somatic mutations (data from TCGA). We further characterize SNPs likely to be very recent in origin (i.e., formed in otherwise congenic mice) and show enrichment for...
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