Article
Comparative analysis of context-dependent mutagenesis using human and mouse models.
BioMed research international - 1 Jan 2013
Medvedeva Sofya A, Panchin Alexander Y, Alexeevski Andrey V, Spirin Sergey A, Panchin Yuri V
Abstract excerpt
Substitution rates strongly depend on their nucleotide context. One of the most studied examples is the excess of C > T mutations in the CG context in various groups of organisms, including vertebrates. Studies on the molecular mechanisms underlying this mutation regularity have provided insights into evolution, mutagenesis, and cancer development. Recently several other hypermutable motifs were identified in the...
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